Anna Albisetti, Célia Florimond, Nicolas Landrein, Keni Vidilaseris, Marie Eggenspieler, Johannes Lesigang, Gang Dong, Derrick Roy Robinson, Mélanie Bonhivers

“Interaction between the Flagellar Pocket Collar and the Hook Complex via a Novel Microtubule-Binding Protein in Trypanosoma Brucei” PLOS Pathogens 13, no. 11 (November 1, 2017): e1006710,

Trypanosoma brucei is the parasite responsible for human African trypanosomiasis, a disease also known as sleeping sickness. African trypanosomiasis is present in Sub-Saharan Africa and transmitted by infected tsetse flies. This devastating disease is lethal if untreated, making it important to understand and characterise the basic biology of the pathogen. During the T. brucei cell cycle, organelle positioning and segregation show a high degree of coordination and control. As such, T. brucei is a highly polarised cell with the transition zone of the flagellum present inside an invagination of the pellicular membrane called the flagellar pocket (FP). The FP is the main site of traffic into and out of the cell. At the exit point of the flagellum is a cytoskeletal structure called the flagellar pocket collar (FPC). One component of the FPC, BILBO1, has been characterised as essential for the FP biogenesis and cell survival. Here, we identify a new partner of BILBO1 called FPC4, and determine the domains involved in the BILBO1-FPC4 interaction. We further highlight the role of FPC4 in the segregation of the FPC and in the interplay between the FPC and other essential cytoskeletal structures.

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