USC-EA 3671

Mycoplasma and Chlamydia
Infections in Humans (IHMC)

Mycoplasma and Chlamydia infections in humans. INRA – University of Bordeaux 146, rue Léo Saignat

33076 Bordeaux Cedex France

Contact

Tel. +33 (0)5 57571625
Fax.+33(0)5 56932940
cecile.bebear@u-bordeaux.fr
www.cnr-ist.fr

Group Leader
Cécile BEBEAR (PU-PH)

Lab members

Sabine PEREYRE (MCU-PH)
Olivia PEUCHANT (MCU-PH)
Charles CAZANAVE (PU-PH)
Thierry SCHAEVERBEKE
Jennifer GUIRAUD (AHU)
Chloé LE ROY (IE)
Nadège HENIN (Tech)
Carla BALCON (AI)
Brigitte COUDERC (SASU)
PhD students

Missions and objectives

The Mycoplasma and Chlamydia Infections in Humans unit is a Research Unit approved by INRA (Unit under contract – USC) and Bordeaux University (Host Team – EA). Internationally renowned for its expertise in the field of human mycoplasma infections for over thirty years, it is a member of the Sciences Biologiques et Médicales research department at Bordeaux University.
Recognised by the Ministry of Health and Public Health France as a National Centre of Reference (CNR) on Chlamydia from 1999 to 2016, it has been appointed as coordinating laboratory of the French CNR on bacterial Sexually Transmitted Infections (STI) from 2017 to 2021. It has a strong partnership with the Bordeaux university Hospital; the unit’s lecturer-researchers are all hospital academics working in the fields of clinical microbiology, infectiology or rheumatology.
The aim of the unit is to develop translational research in clinical microbiology on mycoplasma and chlamydia infections in humans. These bacteria have several characteristics in common. They are responsible for infections of the genital tract and of the respiratory tract and can be involved in chronic diseases such as asthma.
Our aim is to improve understanding of the role of these bacteria to increase knowledge on their epidemiology and improve the methods of diagnosis and treatment of the infections they cause.

 

Scientific areas

1. Comparative and functional genomics of human mycoplasmas, mainly regarding Mycoplasma hominis responsible for urogenital and neonatal infections. Development of genetic tools dedicated to this species.

2. Host-mycoplasma interactions, particularly the interaction of M. hominis with the innate immune system in humans.

3. Epidemiology and diagnosis of mycoplasma and C. trachomatis infections: molecular diagnosis, molecular typing methods, antibiotic susceptibility testing, acquired resistance to antibiotics and epidemiological studies on C. trachomatis, M. pneumoniae, Mycoplasma genitalium, M. hominis, and Ureaplasma spp. infections. This scientific area includes the research activities of the CNR on bacterial STI caused by C. trachomatis and urogenital mycoplasmas. Via the CNR, our unit is strongly involved in clinical research and national PHRC related to STIs. The CNR participates to several ANRS-funded assays related to bacterial STs.

Scientific collaborations and partnerships

Within Bordeaux University, IHMC collaborates closely with the UMR INRA 1332 (mollicutes team) in the field of mycoplasmas. It also collaborates with the UMR CNRS 5164, Bordeaux Functional Genomics Centre (CGFB), and Bordeaux Bioinformatics Centre (CBiB).

National Collaborations : ENVT (UMR INRA 1225), Anses Lyon, Anses Maison Alfort, CEA-Génoscope Evry, CEA Fontenay-aux-Roses, APHP Hospital Saint-Louis, Cochin, Pitié-Salpétrière, Paris-Orsay University, Institut Pasteur and Versailles-Saint Quentin University.

International Collaborations : Statens Serum Institut, Denmark; University of Dresden, Heinrich Heine University, Germany; Hebrew University of Jerusalem, Israel; VU University Medical Centre, University of Maastricht, The Netherlands; Kitasato University, Sapporo Tokushukai Hospital, Japan; Centre for Genomic Regulation (CGR), Spain; Anova Health Institute, South Africa; Uppsala University Hospital, Sweden; Health Protection Agency, University of St Andrews, University of Southampton, the United Kingdom; University of Alabama in Birmingham, University of Washington in Seattle, Mayo clinic in Rochester, USA.

The unit launched the study group on human mycoplasmas (ESGMI) of the European Society of Microbiology and Infectious Diseases (ESCMID) in 2013, which was enlarged to mycoplasmas and chlamydia (ESGMAC) in 2019. This group aims to study and improve the diagnosis, treatment, control, and prevention of mycoplasma and chlamydia infections in humans.