Mycoplasma and Chlamydia
|Mycoplasma and Chlamydia infections in humans. INRA – University of Bordeaux 146, rue Léo Saignat
33076 Bordeaux Cedex France
Sabine PEREYRE (MCU-PH)
Missions and objectives
The Mycoplasma and Chlamydia Infections in Humans unit is a Research Unit approved by INRA (Unit under contract – USC) and Bordeaux University (Host Team – EA). Internationally renowned for its expertise in the field of human mycoplasma infections for over thirty years, it is a member of the Sciences Biologiques et Médicales research department at Bordeaux University.
1. Comparative and functional genomics of human mycoplasmas, mainly regarding Mycoplasma hominis responsible for urogenital and neonatal infections. Development of genetic tools dedicated to this species.
2. Host-mycoplasma interactions, particularly the interaction of M. hominis with the innate immune system in humans.
3. Epidemiology and diagnosis of mycoplasma and C. trachomatis infections: molecular diagnosis, molecular typing methods, antibiotic susceptibility testing, acquired resistance to antibiotics and epidemiological studies on C. trachomatis, M. pneumoniae, Mycoplasma genitalium, M. hominis, and Ureaplasma spp. infections. This scientific area includes the research activities of the CNR on bacterial STI caused by C. trachomatis and urogenital mycoplasmas. Via the CNR, our unit is strongly involved in clinical research and national PHRC related to STIs. The CNR participates to several ANRS-funded assays related to bacterial STs.
Scientific collaborations and partnerships
Within Bordeaux University, IHMC collaborates closely with the UMR INRA 1332 (mollicutes team) in the field of mycoplasmas. It also collaborates with the UMR CNRS 5164, Bordeaux Functional Genomics Centre (CGFB), and Bordeaux Bioinformatics Centre (CBiB).
National Collaborations : ENVT (UMR INRA 1225), Anses Lyon, Anses Maison Alfort, CEA-Génoscope Evry, CEA Fontenay-aux-Roses, APHP Hospital Saint-Louis, Cochin, Pitié-Salpétrière, Paris-Orsay University, Institut Pasteur and Versailles-Saint Quentin University.
International Collaborations : Statens Serum Institut, Denmark; University of Dresden, Heinrich Heine University, Germany; Hebrew University of Jerusalem, Israel; VU University Medical Centre, University of Maastricht, The Netherlands; Kitasato University, Sapporo Tokushukai Hospital, Japan; Centre for Genomic Regulation (CGR), Spain; Anova Health Institute, South Africa; Uppsala University Hospital, Sweden; Health Protection Agency, University of St Andrews, University of Southampton, the United Kingdom; University of Alabama in Birmingham, University of Washington in Seattle, Mayo clinic in Rochester, USA.
The unit launched the study group on human mycoplasmas (ESGMI) of the European Society of Microbiology and Infectious Diseases (ESCMID) in 2013, which was enlarged to mycoplasmas and chlamydia (ESGMAC) in 2019. This group aims to study and improve the diagnosis, treatment, control, and prevention of mycoplasma and chlamydia infections in humans.