Focus sur quelques publications du département SBM

 Focus sur quelques publications du Département Sciences Biologiques et Médicales


Artificial analogues of DNA mimic proteins functionalized

To specifically inhibit therapeutic target as HIV-1 integrase and human Topoisomerase 1

V. Parissi, MFP Bordeaux, P. Pourquier IRC Montpellier, I. Huc, LMU Munich


CRISPR-Cas9 molecular scissors: a bit too sharp?

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations.

Biotherapy team, U1035.

Cullot et al., Nat Commun. 2019

 


On the tail of a new step in HIV-1 replication


Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human

   


MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting β-catenin and Wnt signaling :

http://onlinelibrary.wiley.com/doi/10.1002/hep4.1029/full

New insights into diagnosis and therapeutic options for proliferative hepatoblastoma :

http://onlinelibrary.wiley.com/wol1/doi/10.1002/hep.29672/abstract

 


Functional interactions between retroviral integration complexes and host chromatin unveiled


Anna Albisetti, Célia Florimond, Nicolas Landrein, Keni Vidilaseris, Marie Eggenspieler, Johannes Lesigang, Gang Dong, Derrick Roy Robinson, Mélanie Bonhivers

“Interaction between the Flagellar Pocket Collar and the Hook Complex via a Novel Microtubule-Binding Protein in Trypanosoma Brucei” PLOS Pathogens 13, no. 11 (November 1, 2017): e1006710,

https://doi.org/10.1371/journal.ppat.1006710.


Multi-layered control of autophagy during adenovirus cell entry through a conserved PPxY motif

L’Adénovirus limite l’autophagie induite par les dommages membranaires grâce au motif conservé PPxY de la protéine de capside PVI.

Charlotte Montespan, Harald Wodrich and colleagues

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006217

Commented in an opinion paper (GEMS Journal of Virology)

http://jvi.asm.org/content/early/2017/06/23/JVI.00581-17.abstract


Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC.

Tingaud-Sequeira A, Raldúa D, Lavie J, Mathieu G, Bordier M, Knoll-Gellida A, Rambeau P, Coupry I, André M, Malm E, Möller C, Andreasson S, Rendtorff ND, Tranebjærg L, Koenig M, Lacombe D, Goizet C, Babin PJ.

Neurobiology of Disease 98, 36-51, 2017.

doi: 10.1016/j.nbd.2016.11.008.

PMID: 27890673


mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

Focus sur le projet “CHIMIOKINES” du LAMC – L’INSERM U1029


“Tracking adenovirus genomes identifies morphologically distinct late DNA replication compartments”
.

Komatsu T, Robinson DR, Hisaoka M, Ueshima S, Okuwaki M, Nagata K, Wodrich H.
Traffic. 2016 Aug 5. doi: 10.1111/tra.12429. PMID:27492875


Le livre “Une brève Histoire du Vaisseau Sanguin et lymphatique” est sorti le 23 juin en librairie et a été écrit par Andreas Bikfalvi, directeur de l’unité Inserm U 1029 Laboratoire de l’Angiogenèse et du Microenvironnement des Cancers.
khatibteam
Apelin: an antithrombotic factor that inhibits platelet function”.Adam F, Khatib AM, Lopez JJ, Vatier C, Turpin S, Muscat A, Soulet F, Aries A, Jardin I, Bobe R, Stepanian A, de Prost D, Dray C, Rosado JA, Valet P, Feve B, Siegfried G.

“CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia”.
Gioia R, Trégoat C, Dumas PY, Lagarde V, Prouzet-Mauléon V, Desplat V, Sirvent A, Praloran V, Lippert E, Villacreces A, Leconet W, Robert B, Vigon I, Roche S, Mahon FX, Pasquet JM. J Pathol. 2015 May 12.
parissi-rad51-2015
“hRAD51, un modulateur central de l’intégration du VIH-1”.
Sylvain Thierry1*, Mohamed Salah Benleulmi2¶*, Ludivine Sinzelle2, Eloise Thierry1, Christina Calmels2¶, Stephane Chaignepain3, Pierre Waffo-Teguo4, Jean-Michel Merillon4, Brian Budke5, Jean-Max Pasquet6, Simon Litvak2, Angela Ciuffi7, Patrick Sung8, Philip Connell5, Ilona Hauber9¶,  Joachim Hauber9¶, Marie-Line Andreola2¶, Olivier Delelis1, Vincent Parissi2#
retrovirologyparissi  

“Intasome architecture and chromatin density modulate retroviral integration into nucleosome”.

Mohamed Salah Benleulmi1, Julien Matysiak1, Daniel Rodrigo Henriquez2, Cédric Vaillant3, Paul Lesbats1,8, Christina Calmels1, Monica Naughtin4,9, Oscar Leon2, Anna Marie Skalka5, Marc Ruff6, Marc Lavigne3,7, Marie-Line Andreola1 and Vincent Parissi1* 

 


Analyse total des gênes impliqués dans les processus de régénération chez le poisson zèbre : effet de HIF”

Khatib AM, Lahlil R, Hagedorn M, Delomenie C, Christophe O, Denis C, Siegfried G.  Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis. Oncotarget. 2016 Mar 15;7(11):12102-20. doi: 10.18632/oncotarget.7728.

 


“Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties”.

Delphine Fessart , Charlotte Domblides, Tony Avril, Leif A Eriksson, Hugues Begueret, Raphael Pineau, Camille Malrieux, Nathalie Dugot-Senant, Carlo Lucchesi, Eric Chevet, Frederic Delom

Université de Bordeaux, France; University of Rennes 1, France; University of Gothenburg, Sweden; Hôpital Haut-Lévêque, France; Bergonié Cancer Institute, France

Elife. 2016 May 30;5. pii: e13887. doi: 10.7554/eLife.13887. [Epub ahead of print]
PMID:27240165 Free Article  Similar articles

 


“Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation”.

Escudero JA, Loot C, Parissi V, Nivina A, Bouchier C, Mazel D. Nat Commun. 2016 Mar 10;7:10937. doi: 10.1038/ncomms10937.

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